Related Experiment Video
Updated: May 10, 2026

Establishment of an Extracellular Acidic pH Culture System
Published on: November 19, 2017
Effect of orally administered sodium bicarbonate on caecal pH
E A Taylor1, W L Beard, T Douthit
1Department of Clinical Sciences, Kansas State University, USA.
Reasons For Performing Study:
Caecal acidosis is a central event in the metabolic cascade that occurs following grain overload. Buffering the caecal acidosis by enterally administered sodium bicarbonate (NaHCO3 ) may be beneficial to affected horses.
Objectives:
To determine the effect and duration of enterally administered NaHCO3 on caecal pH in healthy horses.
Study Design:
Experimental study using horses with caecal cannulas.
Methods:
Nine horses had been previously fitted with a caecal cannula. Six horses received 1.0 g/kg bwt NaHCO3 and 3 control horses were given 3 l of water via nasogastric tube. Clinical parameters, water consumption, venous blood gases, caecal pH, faecal pH and faecal water content were measured at 6 h intervals over a 36 h study period.
Results:
Horses that received enterally administered NaHCO3 had significantly increased caecal pH that lasted the duration of the study. Treated horses increased their water intake, and developed metabolic alkalaemia, significantly increased plasma sodium concentrations and significantly decreased plasma potassium concentrations.
Conclusions:
Enterally administered NaHCO3 may be beneficial in buffering caecal acidosis.
More Related Videos
Related Concept Videos
Bicarbonate-Carbonic Acid Buffer
Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids
However, this neutralization reaction between...
Stomach pH Regulation
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
Titration of Polyprotic Base with a Strong Acid
Diagnosing Acidosis and Alkalosis
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2 and HCO3− values are examined to...
Factors Affecting Solubility

