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Related Experiment Video

Updated: May 10, 2026

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation
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Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

C2 subcutaneous stimulation for failed back surgery syndrome: a case report.

Dirk De Ridder1, Mark Plazier, Tomas Menovsky

  • 1Brai2n, TRI & Department of Neurosurgery, University Hospital Antwerp, Edegem, Belgium; Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, New Zealand.

Neuromodulation : Journal of the International Neuromodulation Society
|June 7, 2013
PubMed
Summary

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Electrical stimulation of the C2 area using a burst mode design effectively treated failed back surgery syndrome (FBSS) pain. This neuromodulation approach provided sustained pain relief for over three years.

Area of Science:

  • Neuromodulation
  • Pain Management
  • Spinal Surgery

Background:

  • Failed back surgery syndrome (FBSS) involves persistent low back pain after spinal surgery.
  • Cervical (C2) electrical stimulation has shown potential for pain suppression in animal models.
  • The efficacy of C2 electrical stimulation for human FBSS pain remains largely unexplored.

Observation:

  • A patient with refractory FBSS experienced pain relief with transcutaneous electrical nerve stimulation (TENS) at C2.
  • Allergic reactions to TENS electrodes necessitated an alternative treatment strategy.
  • A subcutaneous C2 electrode was implanted for continuous neuromodulation.

Findings:

  • Testing three stimulation modes (tonic, placebo, burst) revealed burst stimulation as the most effective.
Keywords:
BurstC2 stimulationfailed back surgerypaintonic

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  • The burst stimulation design significantly reduced both mild and severe pain.
  • The patient achieved sustained pain relief for over three years with a fully implanted system.

    • Implications:

    • Subcutaneous C2 neuromodulation, particularly with burst stimulation, offers a promising therapeutic option for FBSS.
    • This case highlights the potential of targeted neuromodulation for intractable chronic pain.
    • Further research into C2 neuromodulation for FBSS is warranted.