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Updated: May 10, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
Network modeling to identify new mechanisms and therapeutic targets for Parkinson's disease
Linda MacArthur1, Habtom Ressom, Salim Shah
1Georgetown University Medical Center, Washington, DC, USA.
Abstract:
Biomolecules in subnetworks are the focus of a new strategy to develop drugs that halt complex diseases. In this article, the authors use genome-wide association study and linkage data derived from Parkinson's disease studies to illustrate how algorithms that use gene and protein interaction databases reveal subnetworks in biological systems that suggest mechanisms for disease progression. Network modeling may help develop testable hypotheses for neurodegenerative diseases and open up new avenues for therapeutic development.
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