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[Developmental dysphasia in children: perspectives of neurotrophic therapy]

N N Zavadenko, E V Kozlova

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |June 7, 2013
    PubMed

    Insights

    Cerebrolysin treatment significantly improved speech and language skills in children with developmental dysphasia (alalia). The therapy also positively impacted behavior, attention, and motor development in young patients.

    Area of Science:

    • Pediatrics
    • Neurology
    • Speech-Language Pathology

    Background:

    • Developmental dysphasia (alalia) is a severe childhood speech and language disorder.
    • Early intervention is crucial for managing developmental dysphasia.

    Purpose of the Study:

    • To evaluate the efficacy of cerebrolysin in treating developmental dysphasia in young children.
    • To assess the impact of cerebrolysin on speech, language, behavior, and motor development.

    Main Methods:

    • A randomized controlled trial involving 60 children aged 3-4 years with developmental dysphasia.
    • Group 1 received cerebrolysin (0.1 ml/kg) for 2 months; Group 2 (controls) received no pharmacotherapy.
    • Speech, language, behavior, and motor development were assessed using standardized measures and parent questionnaires.

    Main Results:

    • Cerebrolysin significantly improved expressive and impressive speech, and speech attention.
    • Active vocabulary increased 3.5-fold and phrase use 5-fold in the treatment group compared to 1.5-fold in controls.
    • Parents reported decreased behavioral issues (psychasthenic, psychosomatic problems, hyperactivity) and improved attention and emotional control.

    Conclusions:

    • Cerebrolysin is an effective treatment for developmental dysphasia, enhancing speech, language, and cognitive functions.
    • The therapy demonstrated positive effects on motor development and overall behavior in affected children.
    • Cerebrolysin offers a promising therapeutic option for children with developmental dysphasia.

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