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Related Experiment Video

Updated: May 10, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

Lobomycosis and squamous cell carcinoma.

Lisiane Nogueira¹, Luciana Mendes, Carlos Alberto Chirano Rodrigues

¹Tropical Medicine Foundation of the Amazonas, Manaus, (AM), Brazil.

Anais Brasileiros De Dermatologia

|June 7, 2013

Summary

Squamous cell carcinoma can arise from chronic ulcers and burn scars. Transformation of old lobomycosis scars into this cancer is rare but highlights the need for vigilant patient monitoring.

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Area of Science:

Oncology
Dermatology
Pathology

Background:

Malignant transformation of chronic wounds, such as long-standing ulcers and burn scars, into squamous cell carcinoma is a well-documented phenomenon.
Various etiologies, including infectious agents, can predispose chronic lesions to cancerous changes.
Squamous cell carcinoma (SCC) is a common skin cancer that develops from squamous cells.

Observation:

The transformation of old lobomycosis lesion scars into squamous cell carcinoma is an infrequently reported occurrence.
Lobomycosis is a chronic fungal infection characterized by keloid-like lesions.

Findings:

This case highlights a rare instance of malignant progression in a chronic, previously infected lesion.
The study underscores that squamous cell carcinoma can develop even in uncommon scar types, like those from lobomycosis.

Implications:

Long-term and careful follow-up of patients with chronic ulcers and scars, including those from rare infections like lobomycosis, is crucial.
Early detection and intervention are vital to prevent the progression of chronic inflammatory or infectious lesions to squamous cell carcinoma.
Understanding the potential for malignant transformation in diverse chronic wound types can improve patient management strategies.