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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Inflammatory Bowel Disease III: Crohn's Disease

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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
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Diseases of the Liver and Gallbladder

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Related Experiment Videos

[Whipple's disease].

Daisuke Watanabe1, Tetsuhiro Kakimoto, Kenta Kodama

  • 1Showa University Yokohama Northern Hospital, Japan. D.W.colon@gmail.com

Nihon Shokakibyo Gakkai Zasshi = the Japanese Journal of Gastro-Enterology
|June 7, 2013
PubMed
Summary
This summary is machine-generated.

Whipple's disease, a rare bacterial infection, was diagnosed in a patient presenting with gastrointestinal symptoms. Early PCR confirmation and prompt antibiotic treatment were crucial for managing this challenging condition.

Related Experiment Videos

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Microbiology

Background:

  • Whipple's disease is a rare systemic bacterial infection caused by Tropheryma whipplei.
  • It often presents with vague gastrointestinal symptoms, making diagnosis challenging.

Observation:

  • A 36-year-old woman presented with fever, diarrhea, and weight loss.
  • Endoscopic examination revealed characteristic yellow-white shaggy mucosa in the duodenum and ileum.
  • Biopsies showed distended villi and foamy macrophages, indicative of Whipple's disease.

Findings:

  • Polymerase Chain Reaction (PCR) confirmed Tropheryma whipplei DNA in duodenal biopsies.
  • Initial treatment with ceftriaxone followed by sulfamethoxazole/trimethoprim was initiated.
  • The patient developed complications of infective endocarditis and meningitis during treatment.

Implications:

  • This case highlights the importance of PCR in diagnosing Whipple's disease.
  • Aggressive antibiotic regimens, including combination therapy with gentamicin, penicillin G, ampicillin, meropenem, and vancomycin, were necessary to manage complications.
  • Prompt diagnosis and comprehensive treatment are vital for successful outcomes in Whipple's disease.