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Cellular proliferation markers in peripheral and central fibromas: a comparative study
Bruna Gonçalves Garcia1, Patrícia Carlos Caldeira, Aline Cristina Batista Rodrigues Johann
1Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Journal of Applied Oral Science : Revista FOB
|June 7, 2013
Summary
Cellular proliferation differs between central and peripheral fibromas, with central lesions showing higher activity. This suggests the mesenchymal component influences biological behavior in these odontogenic tumors.
Area of Science:
- Oral Pathology
- Oncology
- Cell Biology
Background:
- Odontogenic fibromas are tumors with varying clinical presentations.
- Distinguishing between peripheral and central fibromas is crucial for understanding their biological behavior.
Purpose of the Study:
- To compare cellular proliferation in peripheral and central fibromas using PCNA and AgNOR techniques.
- To investigate the role of mesenchymal and epithelial components in fibroma development.
Main Methods:
- Immunohistochemistry for Proliferating Cell Nuclear Antigen (PCNA) and AgNOR staining.
- Analysis of 9 peripheral odontogenic fibromas (POF), 4 odontogenic fibromas (OdF), 8 peripheral ossifying fibromas (PEOF), and 7 ossifying fibromas (OsF).
- Statistical analysis using Kruskal-Wallis and Mann-Whitney tests.
Main Results:
- Central fibroma lesions exhibited significantly higher mean AgNOR counts and PCNA indices in their mesenchymal components compared to peripheral lesions (P≤0.05).
- The epithelial component of Odontogenic Fibroma (OdF) showed a higher mean AgNOR count than Peripheral Odontogenic Fibroma (POF) (P≤0.05).
- Odontogenic fibromas (OdF) and Peripheral Odontogenic Fibromas (POF) displayed similar proliferation indices between their mesenchymal and epithelial components.
Conclusions:
- The mesenchymal component appears to influence the distinct biological behavior observed between central and peripheral fibromas.
- Further research is needed to elucidate the role of epithelial components in the development and behavior of these lesions, particularly given their similar proliferation indices to mesenchymal components in Odontogenic Fibromas.
