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Complementary and alternative medicine in paediatrics: a systematic overview/synthesis of Cochrane Collaboration
Sascha Meyer1, Ludwig Gortner, Alexander Larsen
1University Department of Paediatrics and Neonatology, Children’s Hospital of Saarland, Homburg, Germany. sascha.meyer@uks.eu
Insights
Most pediatric complementary and alternative medicine (CAM) reviews are inconclusive, highlighting a need for high-quality research. Rigorous scientific standards are crucial for CAM to be accepted by mainstream medicine.
Area of Science:
- Pediatric Health Research
- Complementary and Alternative Medicine (CAM) Efficacy
- Evidence-Based Practice in Pediatrics
Background:
- Complementary and Alternative Medicine (CAM) is frequently used by children with chronic illnesses.
- Evidence-based medicine is critical for optimal pediatric patient care.
Purpose of the Study:
- To systematically review Cochrane reviews on the efficacy and clinical implications of CAM in children.
- To synthesize evidence regarding CAM interventions for pediatric chronic conditions.
Main Methods:
- Systematic overview of Cochrane reviews published between 1995 and 2012.
- Analysis of review conclusions on CAM intervention benefits, contraindications, and evidence levels.
- Categorization of reviews by time intervals to assess trends in evidence quality.
Main Results:
- Out of 135 reviews, only 3.7% recommended CAM interventions, while 19.4% offered conditional positive recommendations.
- A significant majority of reviews (70.3%) were inconclusive regarding CAM efficacy.
- The proportion of inconclusive reviews increased over time, with common criticisms including the need for more research, low methodological quality, and small sample sizes.
Conclusions:
- The high rate of inconclusive reviews underscores the need for rigorous, high-quality research into pediatric CAM.
- To gain acceptance in mainstream medicine, CAM interventions must meet the same scientific standards as conventional therapies.
Background:
A high prevalence of complementary and alternative medicine (CAM) use has been documented in children with chronic illnesses. Conversely, evidence-based medicine is considered an important contributor in providing the best quality of care.
Methods:
We performed a systematic overview/synthesis of all Cochrane reviews published between 1995 and 2012 in paediatrics that assessed the efficacy, and clinical implications and limitations of CAM use in children. Main outcome variables were: percentage of reviews that concluded that a certain intervention provides a benefit, percentage of reviews that concluded that a certain intervention should not be performed, and percentage of studies that concluded that the current level of evidence is inconclusive.
Results:
A total of 135 reviews were included - most from the United Kingdom (29/135), Australia (24/135) and China (24/135). Only 5/135 (3.7%) reviews gave a recommendation in favour of a certain intervention; 26/135 (19.4%) issued a conditional positive recommendation, and 9/135 (6.6%) reviews concluded that certain interventions should not be performed. Ninety-five reviews (70.3%) were inconclusive. The proportion of inconclusive reviews increased during three, a priori-defined, time intervals (1995-2000: 15/27 [55.6%]; 2001-2006: 33/44 [75%]; and 2007-2012: 47/64 [73.4%]). The three most common criticisms of the quality of the studies included were: more research needed (82/135), low methodological quality (57/135) and small number of study participants (48/135).
Conclusions:
Given the disproportionate number of inconclusive reviews, there is an ongoing need for high quality research to assess the potential role of CAM in children. Unless the study of CAM is performed to the same science-based standards as conventional therapies, CAM therapies risk being perpetually marginalised by mainstream medicine.
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