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Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide - case reports

Ivana Cristina Fernandez1, María Del Carmen Camberos, Gisel Anabel Passicot

  • 1Hospital de Niños Ricardo Gutierrez, Buenos Aires, Argentina.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|June 7, 2013
PubMed

Insights

Acetyl-L-carnitine and nicotinamide treatment shows promise for children at risk of type 1 diabetes. This intervention may delay or reverse diabetes development in at-risk pediatric populations.

Area of Science:

  • Immunology
  • Endocrinology
  • Pediatrics

Background:

  • Type 1 diabetes (T1D) is an autoimmune disease with increasing incidence in children.
  • Early intervention in at-risk individuals is crucial for preventing disease onset.
  • Identifying effective and safe therapeutic strategies for T1D prevention is a priority.

Observation:

  • A study evaluated acetyl-L-carnitine (ALCAR) and nicotinamide (NIC) in children at risk for T1D.
  • Participants were characterized by HLA-DQB1 and positive autoantibodies.
  • Children with an initial insulin response peak ≤48 µU were randomized into control and treatment groups.

Findings:

  • Treatment with ALCAR and NIC showed positive outcomes in a subset of at-risk children.
  • Four patients recovered their metabolic parameters, leading to medication suspension.
  • Two patients exhibited favorable evolution while continuing treatment; two others showed slow progression with normal development.

Implications:

  • This therapeutic approach may delay or induce remission of T1D in at-risk children.
  • ALCAR and NIC represent a potential strategy for T1D prevention or early management.
  • Further research is warranted to optimize treatment protocols and confirm long-term efficacy.
Abstract

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