Related Experiment Video
Updated: May 10, 2026

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
Published on: September 9, 2022
Mood disorder as the presenting manifestation of demyelination
1Department of Neurology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Mich., USA.
Objective:
To report an unusual presenting manifestation of multiple sclerosis in a teenager.
Case Report:
We report the case of a 16-year-old male who was diagnosed with schizoaffective disorder a year prior to his neurological consultation. Neurological examination showed evidence of mild lower extremity spasticity with ataxia and dysarthria. Imaging revealed lesions suggestive of multiple sclerosis.
Conclusion:
An organic basis for psychiatric disorders is often overlooked. Children presenting with symptoms suggestive of a mood disorder, decline in cognition or psychosis deserve a detailed neurological examination and appropriate imaging if indicated, before starting them on antidepressant or neuroleptic medication.
Related Concept Videos
Multiple Sclerosis l: Introduction
Depressive Disorders: MDD and Dysthymia
Disorders of the Nervous Tissue
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Bipolar Disorder
Encephalitis l: Introduction
Myasthenia Gravis ll: Pathophysiology

