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Related Experiment Videos

Seromuscular enterocystoplasty in dogs.

J L Salle1, J C Fraga, A Lucib

  • 1Division of Pediatric Surgery and Urology, Hospital de Clinicas of Porto Alegre, Brazil.

The Journal of Urology
|August 1, 1990
PubMed
Summary

Researchers explored using intestinal seromuscular segments for bladder augmentation in dogs. While viable, these segments significantly shrank, indicating further study is needed to understand and prevent this retraction.

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Area of Science:

  • Urology
  • Surgical Innovation
  • Tissue Engineering

Background:

  • Bladder augmentation aims to increase bladder capacity.
  • Intestinal segments are commonly used but can cause complications like metabolic issues.
  • Seromuscular intestinal segments offer theoretical advantages by excluding mucosa.

Purpose of the Study:

  • To evaluate the feasibility of using canine intestinal seromuscular segments for bladder augmentation.
  • To assess the viability and urothelialization of these segments.
  • To identify potential challenges, such as tissue shrinkage.

Main Methods:

  • An experimental canine model was established.
  • Bladder augmentation was performed using seromuscular segments of the sigmoid colon (5 dogs) or ileum (5 dogs).

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  • Segments were evaluated after 8 weeks.

    • Main Results:

    • The seromuscular intestinal segments remained viable.
    • Urothelial coverage was observed on the augmented segments.
    • Significant shrinkage of the seromuscular segments was a prominent finding.

    Conclusions:

    • Seromuscular intestinal segments can be viable and urothelialize after bladder augmentation.
    • Intense shrinkage is a significant issue requiring further investigation.
    • The potential benefits of mucosa-free augmentation warrant further research into preventing segment retraction.