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Updated: May 10, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Note: Mobile micro-Raman analyzer integrated with a lab-on-a-chip.

Haibo Li¹, Gang Chen, Yuxin Zhang

¹State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, People's Republic of China.

The Review of Scientific Instruments

|June 8, 2013

Summary

A new mobile micro-Raman microfluidic analyzer offers label-free detection for microfluidic chips. This cost-effective tool provides powerful analytical capabilities for lab-on-a-chip applications.

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Area of Science:

Analytical Chemistry
Microfluidics
Spectroscopy

Background:

Microfluidic systems require advanced analytical tools for in-situ sample analysis.
Label-free and non-destructive detection methods are crucial for preserving sample integrity.

Purpose of the Study:

To design and construct a mobile micro-Raman microfluidic analyzer.
To enable label-free, non-destructive fingerprint detection of samples within microfluidic systems.

Main Methods:

Integration of a Raman detection system and a microscopic imaging system into an optical module.
Incorporation of 3-axis stages with step motors for precise sample positioning.
Design considerations focused on the specific characteristics of microfluidic systems.

Main Results:

The developed analyzer is practical and user-friendly.
Experimental validation confirms the analyzer's functionality.
Demonstrated high performance-to-cost ratio.

Conclusions:

The mobile micro-Raman microfluidic analyzer is a powerful tool for lab-on-a-chip applications.
Its label-free and non-destructive capabilities offer significant advantages.
Potential for wide application in various scientific fields.