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Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
Published on: January 31, 2025
Direct targeting of proteins to lipid droplets demonstrated by time-lapse live cell imaging
Torahiko Tanaka1, Kazumichi Kuroda, Masanori Ikeda
1Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-ku, Tokyo 173-8610, Japan.
Journal of Bioscience and Bioengineering
|June 8, 2013
Abstract:
A protein that specifically targets lipid droplets (LDs) was created by connecting two domains of nonstructural protein 4B containing amphipathic helices from hepatitis C virus. We demonstrated its direct targeting and accumulation to the LD surface by time-lapse live cell imaging, comparable to those observed with adipose differentiation-related protein.

