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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

[Neonatal parechovirus infection, fever, irritability and myositis]

S Eyssette-Guerreau1, P Boize, M Thibault

  • 1Service de pédiatrie, centre hospitalier René-Dubos, 6, avenue de l'Île-de-France, 95300 Pontoise, France. sguerreau@hotmail.com

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|June 8, 2013
PubMed

Insights

Human parechovirus (HPeV) can cause severe illness in newborns, presenting with sepsis-like symptoms and neurological issues. Early HPeV detection is crucial for prompt diagnosis and management in infants.

Area of Science:

  • Virology
  • Neonatal Medicine
  • Pediatric Infectious Diseases

Background:

  • Human parechovirus (HPeV) is a known pathogen linked to central nervous system infections and sepsis-like illnesses in neonates.
  • Common clinical manifestations include fever, seizures, irritability, rash, and encephalitis.

Observation:

  • This report details 4 cases of full-term infants diagnosed with HPeV infection in October 2012.
  • Median age at symptom onset was 15 days, with presentations of sepsis-like illness, gastrointestinal issues, and irritability.
  • Two infants experienced respiratory distress, two developed skin rashes, and two required intensive care unit admission.

Findings:

  • Laboratory findings included normal or mild inflammatory markers, normal or low white blood cell counts, and hepatitis.
  • Notably, elevated muscular enzymes were observed for the first time in 3 of the affected infants.
  • HPeV infection was confirmed via real-time PCR in cerebrospinal fluid and/or blood samples.

Implications:

  • HPeV can lead to severe neonatal disease, necessitating evaluation in infants presenting with similar symptoms.
  • Consideration of HPeV is important in cases of sudden infant death syndrome.
  • This study highlights the potential severity of HPeV in neonates and introduces elevated muscular enzymes as a potential diagnostic marker.

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