Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 10, 2026

A Technique to Functionalize and Self-assemble Macroscopic Nanoparticle-ligand Monolayer Films onto Template-free Substrates
08:09

A Technique to Functionalize and Self-assemble Macroscopic Nanoparticle-ligand Monolayer Films onto Template-free Substrates

Published on: May 9, 2014

ZnO nanoparticle interactions with phospholipid monolayers.

Alex Vakurov1, Guillermo Mokry, Rik Drummond-Brydson

  • 1School of Chemistry, Environmental and Materials Engineering, University of Leeds, Leeds, UK. A.V.Vakourov@leeds.ac.uk

Journal of Colloid and Interface Science
|June 8, 2013
PubMed
Summary

Zinc oxide (ZnO) nanoparticle interactions with lipid monolayers were studied. Smaller ZnO nanoparticles showed stronger interactions, with aggregation and surface coatings reducing this effect.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Radiological examination of the "Braided Lady": A CT-based case study of an Egyptian mummy.

Radiology case reports·2026
Same author

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026
Same author

A comparison of using online market panel members and traditional methods in control recruitment for a case-control study during a national outbreak of STEC O145, United Kingdom.

Epidemiology and infection·2026
Same author

Optimising emergency care in a primary care network.

The British journal of general practice : the journal of the Royal College of General Practitioners·2026
Same author

Genomics Approach Links ROS-Scavenging to Enhanced Lateral Root Development Under Salt Stress in Tomato.

Plant, cell & environment·2026
Same author

Microbial decomposition in experimental single and mass graves: New insights on post-burial interval estimation.

Forensic science international. Genetics·2026

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biophysics

Background:

  • Understanding nanoparticle-lipid interactions is crucial for nanotoxicology and nanomedicine.
  • Phospholipid monolayers serve as model systems for cell membranes.
  • Zinc oxide (ZnO) nanoparticles are widely used, necessitating studies on their biological interactions.

Purpose of the Study:

  • To investigate the interaction between aqueous zinc oxide (ZnO) nanoparticle dispersions and dioleoyl phosphatidylcholine (DOPC) lipid monolayers.
  • To determine how ZnO nanoparticle characteristics (size, aggregation, surface coating) influence their interaction with lipid monolayers.
  • To assess the effect of these interactions on lipid monolayer phase transitions.

Main Methods:

  • Utilized rapid cyclic voltammetry (RCV) to monitor changes in capacitance current peaks.

More Related Videos

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example
08:42

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example

Published on: October 26, 2016

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects
06:42

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects

Published on: September 27, 2024

Related Experiment Videos

Last Updated: May 10, 2026

A Technique to Functionalize and Self-assemble Macroscopic Nanoparticle-ligand Monolayer Films onto Template-free Substrates
08:09

A Technique to Functionalize and Self-assemble Macroscopic Nanoparticle-ligand Monolayer Films onto Template-free Substrates

Published on: May 9, 2014

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example
08:42

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example

Published on: October 26, 2016

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects
06:42

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects

Published on: September 27, 2024

  • Analyzed the impact of ZnO nanoparticle size, aggregation state, and surface coatings (phosphate, fulvic acid) on DOPC monolayer behavior.
  • Compared interactions of commercially sourced and in-house synthesized ZnO nanoparticles.

    • Main Results:

    • Commercial ZnO nanoparticles showed varying interaction strengths inversely related to particle size and aggregation.
    • Freshly prepared Nanosun ZnO nanoparticles (~25 nm) interacted with and penetrated the DOPC monolayer.
    • Aggregation, phosphate, or fulvic acid coatings significantly minimized ZnO-DOPC interactions.
    • Smaller, in-house synthesized ZnO nanoparticles (~6 nm) strongly interacted with the DOPC monolayer without penetration, even when aggregated.

    Conclusions:

    • ZnO nanoparticle size and surface properties critically dictate their interaction with lipid monolayers.
    • Smaller ZnO nanoparticles exhibit stronger interactions, potentially leading to membrane disruption.
    • Surface modifications like aggregation or coatings can mitigate undesirable nanoparticle-lipid interactions.