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Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
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What is low threshold methadone maintenance treatment?

Carol Strike1, Margaret Millson1, Shaun Hopkins2

  • 1Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario M5T 3M7, Canada.

The International Journal on Drug Policy
|June 8, 2013
PubMed
Summary

Low threshold methadone maintenance (MMT) programs reject abstinence as a goal, focusing instead on reducing barriers to treatment and improving retention for opiate-dependent individuals. Challenges arise from differing professional perspectives on practices like drug testing and appointment adherence.

Keywords:
CanadaHarm reductionLow thresholdMethadone maintenanceProgram policies

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Area of Science:

  • Addiction Medicine
  • Public Health
  • Sociology

Background:

  • Low threshold methadone maintenance (MMT) offers an alternative for individuals not seeking abstinence.
  • Exploration of how Canadian MMT programs define and implement low-threshold approaches.

Purpose of the Study:

  • To investigate the definition and practical implementation of low threshold methadone maintenance (MMT) in Canada.
  • To identify challenges faced by MMT programs in reducing barriers and improving client retention.

Main Methods:

  • Semi-structured interviews with 46 clients, 15 nurses/counsellors, and 9 physicians across three low threshold MMT programs.
  • Thematic coding analysis of interview data to understand definitions and implementation of low threshold MMT.

Main Results:

  • Low threshold MMT explicitly rejects abstinence, prioritizing reduced admission barriers and retention.
  • Disagreements among staff regarding practices like urine drug testing and consequences for missed appointments highlight differing priorities.
  • Physicians experience tension between harm reduction (poly-drug use) and patient well-being.

Conclusions:

  • Current literature may not fully capture the diverse strategies for reducing MMT barriers.
  • Findings are crucial for addressing global opiate dependence and expanding MMT access.
  • Further evaluation of policies and practices is needed to optimize MMT's effectiveness in reducing barriers and enhancing retention.