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Lineage of bone marrow-derived cells in atherosclerosis

Hiroshi Iwata1, Ichiro Manabe, Ryozo Nagai

  • 1Center for Interdisciplinary Cardiovascular Sciences, Harvard Medical School, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. hiroiwata-circ@umin.ac.jp

Circulation Research
|June 8, 2013
PubMed

Insights

Bone marrow-derived cells, including myeloid and vascular progenitor cells, play complex roles in atherosclerosis, a chronic inflammatory disease. Understanding these roles may reveal new therapeutic targets for atherosclerosis treatment.

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Cell Biology

Background:

  • Atherosclerosis is a chronic inflammatory disease influenced by lipids and atherogenic factors.
  • Bone marrow-derived cells, including immune cells and vascular progenitor cells, are increasingly recognized for their roles in atherogenesis.
  • The precise functions and lineage identities of these cells in atherosclerosis remain areas of active investigation.

Purpose of the Study:

  • To review the current understanding of bone marrow-derived cell contributions to atherosclerosis.
  • To highlight the specific roles of myeloid cells and vascular progenitor cells in the disease process.
  • To identify knowledge gaps regarding cellular identity and function in atherosclerosis.

Main Methods:

  • Literature review of recent studies on bone marrow-derived cells in atherosclerosis.
  • Synthesis of information on immune cell subsets and vascular progenitor cells.
  • Analysis of current uncertainties in cellular lineage and function.

Main Results:

  • Bone marrow-derived cells exhibit diverse and dynamic roles in the pathological process of atherosclerosis.
  • Myeloid cells and vascular progenitor cells are key contributors to atherosclerosis development and progression.
  • Significant uncertainties persist regarding the specific identities and functions of various bone marrow-derived cell subsets.

Conclusions:

  • A comprehensive understanding of bone marrow-derived cell subsets is crucial for advancing atherosclerosis research.
  • Further investigation into the pathological roles of these cells may uncover novel therapeutic targets.
  • Targeting specific bone marrow-derived cell pathways holds promise for future atherosclerosis treatment strategies.

Keywords:
atherosclerosisbone marrow–derived cellsinflammationprogenitors

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