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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

Screening for active tuberculosis: methodological challenges in implementation and evaluation.

J E Golub1, D W Dowdy

  • 1Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA. jgolub@jhmi.edu

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|June 8, 2013
PubMed
Summary
This summary is machine-generated.

Designing effective tuberculosis (TB) screening requires addressing key challenges across four continua: disease/yield, risk/resources, strategy, and impact measurement. This review guides the development of impactful TB screening programs.

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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
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Published on: July 28, 2023

Area of Science:

  • Public Health
  • Infectious Disease Epidemiology
  • Global Health

Background:

  • Active screening for tuberculosis (TB) is expanding globally.
  • Effective implementation faces significant methodological hurdles.
  • Understanding these challenges is crucial for program success.

Purpose of the Study:

  • To identify and discuss the primary methodological challenges in designing and implementing TB screening strategies.
  • To provide guidance for developing effective TB screening approaches tailored to specific epidemiological contexts.

Main Methods:

  • This study is a review of existing literature and expert knowledge on TB screening.
  • Challenges are categorized along four key continua: TB disease and diagnostic yield, TB risk and resource availability, TB screening strategies, and outcomes and impact measurements.

Main Results:

  • TB screening design is complex, involving trade-offs across diagnostic accuracy, resource allocation, and strategic implementation.
  • Key challenges include balancing disease detection with diagnostic yield, aligning screening intensity with TB risk and available resources, selecting appropriate screening strategies, and accurately measuring program outcomes and impact.

Conclusions:

  • Addressing the identified continua of challenges is essential for optimizing the design and implementation of TB screening programs worldwide.
  • Effective TB screening strategies must be context-specific, considering epidemiological setting, resource availability, and measurable impact.