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[Diagnosis and treatment of ANCA-associated vasculitis : S3 guideline of the German Society for Rheumatology and Clinical Immunology e. V. (DGRh) and German Society for Internal Medicine e. V. (DGIM), German Society for Nephrology e. V. (DGfN), German Society for ENT Medicine and Head and Neck Surgery e. V. (DGHNO-KHC), German Ophthalmological Society e. V. (DOG), German Society for Neurology e. V. (DGN), German Society for Pneumology and Respiratory Medicine e. V. (DGP), German Society for Pathology e. V. (DGP), German Radiological Society, Society for Medical Radiology e. V. (DRG), Federal Association of German Pathologists, Federal Kidney Association e. V., German Rheumatism League Federal Association e. V.]

Zeitschrift fur Rheumatologie·2025
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[Diagnosis and treatment of ANCA-associated vasculitis : SHORT VERSION of the S3 guideline of the German Society for Rheumatology and Clinical Immunology e. V. (DGRh) and German Society for Internal Medicine e. V. (DGIM), German Society for Nephrology e. V. (DGfN), German Society for Otorhinolaryngology and Head and Neck Surgery e. V. (DGHNO-KHC), German Ophthalmological Society e. V. (DOG), German Society for Neurology e. V. (DGN), German Society for Pneumology and Respiratory Medicine e. V. (DGP), German Society for Pathology e. V. (DGP), German Radiological Society, Society for Medical Radiology e. V. (DRG), Federal Association of German Pathologists, Federal Kidney Association e. V., German Rheumatism League Federal Association e. V.]

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Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography
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[ANCA-associated vasculitis].

J U Holle1

  • 1Poliklinik für Rheumatologie, UKSH, Campus Lübeck, Klinikum Bad Bramstedt, Oskar-Alexander Str. 26, 24576, Bad Bramstedt, Deutschland. j.holle@klinikumbb.de

Zeitschrift Fur Rheumatologie
|June 8, 2013
PubMed
Summary
This summary is machine-generated.

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides, including granulomatosis with polyangiitis, involve small to medium-sized blood vessels. Treatment strategies combine conventional immunosuppressants with newer biologic therapies like rituximab for remission induction and maintenance.

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Area of Science:

  • Rheumatology
  • Immunology
  • Nephrology

Context:

  • Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) encompass several distinct conditions.
  • These diseases are characterized by inflammation of small to medium-sized blood vessels.
  • Vasculitic manifestations can affect virtually any organ system, leading to diverse clinical presentations.

Purpose:

  • To provide an overview of the classification and treatment of ANCA-associated vasculitides.
  • To highlight the current therapeutic landscape, including conventional and biologic agents.

Summary:

  • Granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis are key forms of AAV.
  • Treatment follows a structured approach with initial remission induction and subsequent maintenance therapy.
  • Established treatments involve glucocorticoids and conventional immunosuppressants, complemented by emerging biologic therapies such as rituximab.

Impact:

  • Improved understanding of AAV pathogenesis and classification.
  • Guidance on evidence-based treatment strategies for clinicians.
  • Potential for enhanced patient outcomes through optimized therapeutic regimens, including biologics.