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Updated: May 10, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Mediterranean diet, kidney function, and mortality in men with CKD.

Xiaoyan Huang¹, José Juan Jiménez-Moleón, Bengt Lindholm

¹Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, Stockholm, Sweden. xiaoyan.huang@ki.se

Clinical Journal of the American Society of Nephrology : CJASN

|June 8, 2013

Summary

Adhering to a Mediterranean diet is linked to a lower risk of chronic kidney disease (CKD) and improved survival in elderly men. This dietary pattern may offer protective benefits for kidney health and longevity.

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Area of Science:

Gerontology
Nephrology
Nutritional Science

Background:

Chronic kidney disease (CKD) affects kidney function and is associated with increased mortality risk.
The Mediterranean diet is recognized for its potential health benefits, including cardiovascular protection.

Purpose of the Study:

To investigate the association between adherence to a Mediterranean diet and the prevalence of CKD in elderly men.
To examine the relationship between Mediterranean diet adherence and mortality risk in individuals with established CKD.

Main Methods:

A population-based cohort study of 1110 Swedish men aged 70 years was conducted.
Dietary habits were assessed using 7-day records, and a Mediterranean Diet Score was calculated.
CKD was defined as a glomerular filtration rate (GFR) <60 ml/min per 1.73 m(2), and mortality was tracked over a median of 9.9 years.

Main Results:

Higher adherence to the Mediterranean diet was associated with a significantly lower likelihood of having CKD (42% less likely for high adherents).
Among individuals with CKD, greater adherence correlated with lower phosphate intake and net endogenous acid production.
Mediterranean diet adherence was linked to a reduced mortality risk in patients with manifest CKD, although not statistically significant in all analyses.

Conclusions:

Adherence to a Mediterranean diet is associated with a reduced prevalence of CKD in elderly men.
Greater adherence to this diet independently predicted better survival in individuals with manifest CKD.
Clinical trials are recommended to confirm the benefits of the Mediterranean diet for CKD outcomes.