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Updated: May 10, 2026

In Vivo Mouse Model of Spinal Implant Infection
Published on: June 23, 2020
Chronic infections of the spine
Teresa Bas1, Paloma Bas, Alejandro Blasco
1Unidad de Raquis, Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario y Politécnico La FE, Valencia, Spain. teresabas@gmail.com
Abstract:
Chronic infections following posterior fusion are relatively uncommon. They develop in a previous asymptomatic patient at a distant time from the surgery. Chronic infections arise from direct inoculation or hematogenous seeding. To eradicate a chronic infection, the pathogens, biofilm, non-viable tissues, adherence on surfaces, and instrumentation must be removed. The appropriate antibiotherapy is used in a short (4 weeks) or long protocol (9 weeks). Some patients may need repeated surgeries (leaving the instrumentation in situ) to avoid progressive deformity or symptomatic pseudoarthrosis in cases of implant removal.
Insights
Chronic infections after posterior spinal fusion are rare but serious. Eradicating these infections requires removing pathogens, biofilm, and affected tissues, often necessitating prolonged antibiotic treatment and potentially repeat surgeries.
Area of Science:
- Spine surgery
- Infectious diseases
- Orthopedics
Background:
- Chronic infections post-posterior fusion are uncommon.
- These infections can occur long after initial surgery.
- They stem from direct inoculation or hematogenous spread.
Purpose of the Study:
- To outline the challenges and management strategies for chronic infections following posterior spinal fusion.
- To detail the necessary components for eradicating these deep-seated infections.
- To discuss treatment protocols including surgical intervention and antibiotic therapy.
Main Methods:
- Surgical debridement to remove pathogens, biofilm, non-viable tissues, and instrumentation.
- Administration of appropriate antibiotic therapy (short or long protocols).
- Consideration of repeat surgeries to manage complications like deformity or pseudoarthrosis.
Main Results:
- Successful eradication depends on thorough removal of infectious material and instrumentation.
- Antimicrobial therapy protocols vary in duration (4-9 weeks).
- Some cases require re-operation to preserve spinal stability and alignment.
Conclusions:
- Management of chronic post-fusion infections is complex, requiring a multi-faceted approach.
- Surgical intervention combined with targeted antibiotherapy is crucial for successful outcomes.
- Careful consideration of repeat surgery is vital to prevent long-term complications.
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