Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Screening for Neurodevelopmental Disorders in Japanese 18- and 36-Month Health Check-Ups: Utility and Reproducibility of the ESSENCE-Q.

Acta paediatrica (Oslo, Norway : 1992)·2026
Same author

Probability of a timely vocal response in mother-infant interaction and later psychiatric diagnosis: A case-control study.

PloS one·2026
Same author

The proportion of intellectual disability in autism spectrum disorder over two decades.

Psychiatry research·2026
Same author

Traits of autism and attention-deficit/hyperactivity disorder in irritable bowel syndrome with pronounced symptoms.

Scandinavian journal of gastroenterology·2026
Same author

Mortality in Autism: A Longitudinal Register-Based Study.

Journal of autism and developmental disorders·2026
Same author

Autism and attachment disorder symptoms in the general population: Prevalence, overlap, and burden.

Developmental child welfare·2026

Related Experiment Video

Updated: May 10, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Progress toward treatments for synaptic defects in autism.

Richard Delorme1, Elodie Ey, Roberto Toro

  • 1Institut Pasteur, Human Genetics and Cognitive Functions Unit, Paris, France.

Nature Medicine
|June 8, 2013
PubMed
Summary

Autism spectrum disorder (ASD) has genetic links and affects social communication. Mouse models suggest adult intervention may alleviate symptoms, prompting human synaptic trials.

More Related Videos

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

Related Experiment Videos

Last Updated: May 10, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

Area of Science:

  • Neurodevelopmental disorders
  • Genetics of Autism Spectrum Disorder
  • Synaptic plasticity and homeostasis

Background:

  • Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by social-communication deficits and repetitive behaviors.
  • While the exact cause of ASD is often unknown, genetic factors are implicated in at least 20% of cases.
  • Current treatments do not cure ASD, but research in mouse models suggests potential for symptom alleviation in adulthood.

Purpose of the Study:

  • To explore the potential for therapeutic interventions targeting synaptic pathways in ASD.
  • To investigate whether phenotypic reversals observed in mouse models of ASD can be replicated in human subjects.
  • To propose the design of targeted 'synaptic clinical trials' for ASD.

Main Methods:

  • Review of existing research on ASD genetics and neurobiology.
  • Analysis of findings from mouse models of ASD related to synaptic function.
  • Conceptual framework development for human clinical trials focused on synaptic mechanisms.

Main Results:

  • Genetic factors converge on pathways affecting synaptic homeostasis in ASD.
  • Mouse models demonstrate that some ASD-related phenotypes can be improved even in adult animals.
  • The heterogeneity of ASD suggests a need for precise therapeutic targets.

Conclusions:

  • Targeting synaptic pathways holds promise for ASD treatment.
  • Human clinical trials focusing on synaptic function are warranted to explore potential phenotype reversals.
  • The clinical heterogeneity of ASD necessitates tailored, mechanism-based therapeutic strategies.