Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A stratified binomial marker model for bone-marrow repopulation experiments.

M Stone1, D Harrison

  • 1Department of Statistical Science, University College London, U.K.

Journal of Theoretical Biology
|May 22, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vulnerability and Pediatric Pain.

Paediatric & neonatal pain·2026
Same author

First national study on genomic profiling of <i>Escherichia coli</i> in United Arab Emirates (UAE) aquatic environments shows diverse Quinolone and Cephalosporin resistance.

Environmental challenges (Amsterdam, Netherlands)·2025
Same author

Estimated US Trends in SARS-CoV-2 Spike Antibody Concentrations and Correlation to Risk of First-Time Infections Based on Blood Donations, 2022.

The Journal of infectious diseases·2025
Same author

Advancing mechanistic understanding of cohesive sediment transport: Integrating flume experiments, field measurements, and modelling approaches in a gravel-bed river.

The Science of the total environment·2024
Same author

Veterinary Services'use of the Global Burden of Animal Diseases to prioritise interventions, monitor impact and develop critical competencies.

Revue scientifique et technique (International Office of Epizootics)·2024
Same author

Romosozumab in patients who experienced an on-study fracture: post hoc analyses of the FRAME and ARCH phase 3 trials.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2024
Same journal

The male-biased sex ratio in humans and its role in the transition from promiscuity to pair bonding.

Journal of theoretical biology·2026
Same journal

Quantifying the counter-intuitive effects of vaccination by coupling the transmission dynamics of COVID-19 and the evolution of human behaviors.

Journal of theoretical biology·2026
Same journal

An integrative model of FGF2-induced signaling and muscle cell proliferation.

Journal of theoretical biology·2026
Same journal

A hybrid reaction-diffusion and mechanical stimulus model for mandibular bone remodeling under chewing and vibratory loading.

Journal of theoretical biology·2026
Same journal

Integrated tick management strategies in fragmented peridomestic environments.

Journal of theoretical biology·2026
Same journal

Joint likelihood-free inference of the number of selected single nucleotide polymorphisms and their selection coefficients in an evolving population.

Journal of theoretical biology·2026
See all related articles

This study analyzes bone marrow cell repopulation using a stratified binomial model. Findings reveal insights into cell development and "two-cell probabilities" for genetically marked cell mixtures.

Area of Science:

  • Biomedical research
  • Cell biology
  • Genetics

Background:

  • Bone marrow transplantation involves repopulating the marrow with donor cells.
  • Understanding the behavior of genetically marked cells is crucial for transplantation success.
  • Previous models did not fully account for cell proportion variations within mixtures.

Purpose of the Study:

  • To analyze the covariance of cell proportions in bone marrow repopulation experiments.
  • To develop a stratified binomial model for genetically marked cell mixtures.
  • To explore inferences about "two-cell probabilities" in cell development.

Main Methods:

  • Utilizing bone-marrow repopulation experiments with two types of genetically marked donor cells (A and B).
  • Applying a stratified binomial model to analyze the covariance of cell proportions.

Related Experiment Videos

  • Assuming genetic markers do not influence cell development.

    • Main Results:

    • The covariance of erythrocyte and lymphocyte proportions was analyzed as a sum of two components.
    • Each component of the covariance has a distinct "demographic" interpretation.
    • The ratio of these components is not experimentally estimable.

    Conclusions:

    • The stratified binomial model provides a framework for understanding cell mixtures.
    • The study derives possible inferences about "two-cell probabilities".
    • Experimental findings necessitating the stratified model are illustrated.