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Peripheral Artery Disease III: Interprofessional Care

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Peripheral Artery Disease IV: Nursing Management

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Related Experiment Video

Updated: May 10, 2026

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication
14:52

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Published on: December 11, 2013

Ginkgo biloba for intermittent claudication.

Saskia P A Nicolaï1, Lotte M Kruidenier, Bianca L W Bendermacher

  • 1Department of General Practice, Maastricht University, Maastricht, Netherlands.

The Cochrane Database of Systematic Reviews
|June 8, 2013
PubMed
Summary
This summary is machine-generated.

Ginkgo biloba does not significantly improve walking distance for intermittent claudication (IC) patients. This review found no clinically meaningful benefit, suggesting other treatments may be more effective for peripheral arterial disease.

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Area of Science:

  • Vascular Medicine
  • Pharmacology
  • Clinical Trials

Background:

  • Intermittent claudication (IC) causes leg pain during exercise, relieved by rest.
  • Exercise therapy and medications are common treatments for IC.
  • Ginkgo biloba, a vasoactive agent, is explored for IC symptom management.

Purpose of the Study:

  • To evaluate the efficacy of Ginkgo biloba in enhancing walking distance for individuals with intermittent claudication.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials comparing Ginkgo biloba to placebo.
  • Searched Cochrane Peripheral Vascular Diseases Group Trials Register and CENTRAL.
  • Standardized walking distance using caloric expenditure derived from treadmill parameters.

Main Results:

  • Included 14 trials with 739 participants; 11 trials (477 participants) compared Ginkgo biloba to placebo.
  • Ginkgo biloba showed a non-significant increase in absolute claudication distance (ACD) (effect size 3.57 kcal, P=0.06).
  • This translates to a minimal increase of 64.5 meters, with potential inflation due to publication bias.

Conclusions:

  • Current evidence does not support a clinically significant benefit of Ginkgo biloba for peripheral arterial disease patients.
  • The study highlights the need for further research into effective treatments for intermittent claudication.