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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

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Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
06:32

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Published on: November 4, 2022

Bone cancer.

J Sybil Biermann1, Douglas R Adkins, Mark Agulnik

  • 1University of Michigan Comprehensive Cancer Center, USA.

Journal of the National Comprehensive Cancer Network : JNCCN
|June 8, 2013
PubMed
Summary
This summary is machine-generated.

Primary bone cancers, like chordoma and osteosarcoma, are rare. Effective management requires a multidisciplinary team and long-term surveillance for treatment side effects.

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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Area of Science:

  • Oncology
  • Orthopedics
  • Radiology

Background:

  • Primary bone cancers are rare, representing less than 0.2% of all cancer diagnoses.
  • Effective management necessitates a collaborative, multidisciplinary approach involving various medical specialists.
  • Long-term surveillance is crucial for managing treatment sequelae.

Purpose of the Study:

  • To provide guidelines for the management of specific primary bone cancers.
  • To outline the essential components of a multidisciplinary team for bone cancer care.
  • To emphasize the importance of long-term follow-up in bone cancer treatment.

Main Methods:

  • Review of current literature and clinical practices for bone cancer management.
  • Consensus-building among experts in musculoskeletal oncology, medical oncology, radiation oncology, surgery, and radiology.
  • Development of evidence-based recommendations for evaluation, treatment, and surveillance.

Main Results:

  • Detailed management strategies for chordoma, giant cell tumor of the bone, and osteosarcoma.
  • Identification of key roles and expertise required for a multidisciplinary bone cancer team.
  • Emphasis on comprehensive long-term follow-up protocols to address treatment late effects.

Conclusions:

  • Optimal care for primary bone cancers hinges on a coordinated, multidisciplinary team approach.
  • Specific guidelines are presented for managing chordoma, giant cell tumor of the bone, and osteosarcoma.
  • Long-term patient surveillance is integral to addressing the complexities of bone cancer treatment and recovery.