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Related Experiment Video

Updated: May 10, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

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Published on: October 13, 2023

Characterising aggressive multiple sclerosis.

Suresh Menon1, Afsaneh Shirani, Yinshan Zhao

  • 1Department of Medicine, Division of Neurology, University of British Columbia, , Vancouver, British Columbia, Canada.

Journal of Neurology, Neurosurgery, and Psychiatry
|June 8, 2013
PubMed
Summary
This summary is machine-generated.

Aggressive multiple sclerosis (AMS) affects 4-14% of adult-onset patients. While males and primary progressive MS were more likely to present with AMS, most affected individuals were women with relapsing-onset MS.

Keywords:
CLINICAL NEUROLOGYEPIDEMIOLOGYMULTIPLE SCLEROSISNEUROEPIDEMIOLOGY

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Area of Science:

  • Neurology
  • Immunology
  • Clinical Medicine

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Aggressive multiple sclerosis (AMS) represents a subset of MS with rapid disease progression and disability.
  • Understanding the characteristics of AMS is crucial for early diagnosis and effective management.

Purpose of the Study:

  • To investigate the prevalence and clinical features of aggressive multiple sclerosis (AMS) in adult-onset multiple sclerosis (MS) patients.
  • To identify demographic and clinical factors associated with AMS.
  • To compare characteristics between patients with AMS and non-aggressive MS cohorts.

Main Methods:

  • Retrospective analysis of prospectively collected data from British Columbia, Canada (1980-2009).
  • Defined AMS using three criteria: rapid disability progression (AMS1), early-onset severe disability (AMS2), and rapid progression to secondary progressive MS (AMS3).
  • Utilized multivariable logistic regression to compare patient characteristics between aggressive and non-aggressive MS cohorts, reporting adjusted odds ratios (AOR) and 95% confidence intervals (CI).

Main Results:

  • The prevalence of AMS varied from 4.0% to 14.0% based on the definition used.
  • Patients with AMS were more likely to be male (AOR 1.5-1.8) and older at symptom onset (AOR 1.1).
  • Primary progressive MS was associated with a higher likelihood of AMS (AOR 2.3-2.7), though the majority of AMS patients had relapsing-onset MS and were female.

Conclusions:

  • Aggressive multiple sclerosis (AMS) is identified in a notable percentage of adult-onset MS patients, with prevalence varying by definition.
  • While male sex and primary progressive MS are associated with AMS, women and those with relapsing-onset MS constitute the majority of AMS cases.
  • These findings highlight the heterogeneity of MS and underscore the need for precise definitions and tailored treatment strategies for aggressive forms of the disease.