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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: May 10, 2026

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Cancer epigenetics: a brief review.

Shama Virani, Shami Virani1, Justin A Colacino

  • 1Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor 48109, USA.

ILAR Journal
|June 8, 2013
PubMed
Summary

Epigenetic alterations drive cancer development, but their role in carcinogenesis is not fully understood. Reversible epigenetic changes offer promising therapeutic targets for cancer treatment.

Keywords:
cancerchromatinepigeneticshistonesmechanismsmethylation

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Related Experiment Videos

Last Updated: May 10, 2026

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Cancer arises from accumulated genetic and epigenetic changes.
  • The precise contribution of epigenetics to carcinogenesis requires further elucidation.
  • Epigenetic mechanisms link environmental factors and genetic predisposition to cancer progression.

Purpose of the Study:

  • To review the principles of epigenetics in the context of carcinogenesis.
  • To highlight the potential of epigenetic alterations as therapeutic targets.
  • To discuss the utility of in vivo models for studying epigenetic mechanisms in cancer.

Main Methods:

  • Review of existing literature on epigenetics and carcinogenesis.
  • Discussion of in vivo models for characterizing epigenetic mechanisms.
  • Analysis of studies evaluating epigenetic drugs like decitabine and zebularine.

Main Results:

  • Epigenetic alterations are fundamental to cancer development.
  • In vivo models facilitate the study of epigenetic links between exposures/susceptibility and cancer.
  • Epigenetic drugs demonstrate potential for cancer treatment by targeting reversible alterations.

Conclusions:

  • Epigenetic modifications play a critical role in cancer initiation and progression.
  • The reversibility of epigenetic changes offers significant therapeutic promise.
  • Integrating laboratory and epidemiological data is crucial for effective cancer prevention and treatment.