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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
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Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...

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Updated: May 10, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Comorbidity in Atopic Dermatitis.

Eric L Simpson1

  • 1Oregon Health & Science University, Department of Dermatology, Portland, Oregon USA.

Current Dermatology Reports
|June 8, 2013
PubMed
Summary
This summary is machine-generated.

Atopic dermatitis (AD) impacts more than skin, increasing risks for infections, mental health issues, and allergies. Research suggests a compromised skin barrier initiates AD and its associated conditions.

Keywords:
Comorbidityasthmaatopic dermatitisattention-deficit-hyperactivity-disorderautismcancerdepressioneczemaepicutaneous sensitizationfood allergyskin barrier

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Last Updated: May 10, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

Area of Science:

  • Dermatology and Immunology
  • Epidemiology
  • Genetics

Background:

  • Atopic dermatitis (AD) negatively impacts patients beyond skin manifestations.
  • Children with AD show higher incidences of infectious, allergic, and mental health diseases.
  • The underlying mechanisms connecting AD to these comorbidities are not fully understood.

Purpose of the Study:

  • To review recent literature on established and emerging comorbidities associated with atopic dermatitis.
  • To explore the role of the skin barrier and epicutaneous sensitization in AD pathogenesis and disease associations.

Main Methods:

  • Literature review of recent epidemiological, genetic, and epidermal research.
  • Analysis of studies investigating the link between skin barrier dysfunction and AD comorbidities.
  • Examination of the epicutaneous sensitization model in relation to IgE-mediated diseases.

Main Results:

  • Genetic and epidermal research highlights the skin barrier as a key initiator of AD.
  • Epicutaneous sensitization provides a model linking a disrupted skin barrier to IgE-mediated diseases.
  • New epidemiological data reveal associations between AD and mental health disorders, including obesity.

Conclusions:

  • The skin barrier is a critical factor in the initiation of atopic dermatitis.
  • Atopic dermatitis is associated with a spectrum of comorbidities, including infectious, allergic, and mental health conditions.
  • Further research is needed to elucidate the mechanisms driving these complex associations.