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Comorbidity in Atopic Dermatitis

Eric L Simpson1

  • 1Oregon Health & Science University, Department of Dermatology, Portland, Oregon USA.

Current Dermatology Reports
|June 8, 2013
PubMed

Insights

Atopic dermatitis (AD) impacts more than skin, increasing risks for infections, mental health issues, and allergies. Research suggests a compromised skin barrier initiates AD and its associated conditions.

Area of Science:

  • Dermatology and Immunology
  • Epidemiology
  • Genetics

Background:

  • Atopic dermatitis (AD) negatively impacts patients beyond skin manifestations.
  • Children with AD show higher incidences of infectious, allergic, and mental health diseases.
  • The underlying mechanisms connecting AD to these comorbidities are not fully understood.

Purpose of the Study:

  • To review recent literature on established and emerging comorbidities associated with atopic dermatitis.
  • To explore the role of the skin barrier and epicutaneous sensitization in AD pathogenesis and disease associations.

Main Methods:

  • Literature review of recent epidemiological, genetic, and epidermal research.
  • Analysis of studies investigating the link between skin barrier dysfunction and AD comorbidities.
  • Examination of the epicutaneous sensitization model in relation to IgE-mediated diseases.

Main Results:

  • Genetic and epidermal research highlights the skin barrier as a key initiator of AD.
  • Epicutaneous sensitization provides a model linking a disrupted skin barrier to IgE-mediated diseases.
  • New epidemiological data reveal associations between AD and mental health disorders, including obesity.

Conclusions:

  • The skin barrier is a critical factor in the initiation of atopic dermatitis.
  • Atopic dermatitis is associated with a spectrum of comorbidities, including infectious, allergic, and mental health conditions.
  • Further research is needed to elucidate the mechanisms driving these complex associations.

Keywords:
Comorbidityasthmaatopic dermatitisattention-deficit-hyperactivity-disorderautismcancerdepressioneczemaepicutaneous sensitizationfood allergyskin barrier

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