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Left atrial coagulation activity in patient with mitral stenosis in sinus rhythm

Songsak Kiatchoosakun1, Chaiyasith Wongvipaporn, Nantarat Komanasin

  • 1Division of Cardiology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. sonkia@kku.ac.th

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|June 11, 2013
PubMed

Insights

Coagulation activity in mitral stenosis patients is similar in sinus rhythm and atrial fibrillation. This suggests anticoagulation therapy may benefit patients regardless of heart rhythm.

Area of Science:

  • Cardiology
  • Hematology
  • Biochemistry

Background:

  • Anticoagulation is recommended for mitral stenosis (MS) with atrial fibrillation (AF).
  • Its use in MS patients with sinus rhythm (SR) is debated.
  • Understanding coagulation in MS patients with different rhythms is crucial.

Purpose of the Study:

  • To compare coagulation activity in MS patients with SR versus AF.
  • To evaluate markers of thrombin generation and fibrinolysis.

Main Methods:

  • Studied 35 MS patients undergoing percutaneous balloon mitral valvotomy.
  • Measured atrial blood levels of thrombin-antithrombin complex, fibrinogen, factor XIII, and D-dimer.
  • Compared these markers between patients in SR (n=18) and AF (n=17).

Main Results:

  • No significant differences in thrombin-antithrombin complex, fibrinogen, factor XIII, or D-dimer levels were found between MS patients in SR and AF.
  • Coagulation marker levels did not correlate with left atrial size.

Conclusions:

  • Coagulation activity in the left atrium is comparable in MS patients with SR and AF.
  • These findings support considering anticoagulation therapy for MS patients in SR.
Abstract

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