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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
[Soluble selectins in myocardial infarction]
Magdalena Lampka1, Zofia Grabczewska, Maria Krajewska
1Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum. lampka@cm.umk.pl
Insights
In myocardial infarction, serum soluble L-selectin levels decreased, suggesting leukocyte functional depletion. Soluble E- and P-selectin levels did not adequately reflect endothelial activation in these patients.
Area of Science:
- Cardiovascular Medicine
- Immunology
- Biochemistry
Background:
- Endothelial activation and leukocyte migration are key in myocardial infarction (MI) ischemic injury.
- Selectins, shed into the bloodstream, may serve as markers for endothelial activation and leukocyte stimulation.
Purpose of the Study:
- To evaluate serum soluble E- and P-selectin levels as markers of endothelial activation.
- To assess serum soluble L-selectin levels as a marker of leukocyte stimulation in patients with MI.
Main Methods:
- Analyzed serum concentrations of soluble E-, P-, and L-selectins in 27 acute myocardial infarction (AMI) patients and 23 healthy controls.
- Included routine laboratory tests such as lipid levels, leukocyte count, and prothrombin time in statistical analysis.
Main Results:
- Serum soluble L-selectin levels were significantly lower in AMI patients compared to controls.
- No significant difference in serum soluble E- and P-selectin levels was observed between AMI patients and controls.
- Soluble E-selectin correlated with lipid profiles, while soluble P-selectin correlated with leukocyte count and prothrombin time.
Conclusions:
- Serum soluble E- and P-selectin levels may not be adequate markers for endothelial activation in MI.
- Decreased soluble L-selectin levels might indicate functional leukocyte depletion in MI patients.
- Inflammatory and prothrombotic processes influence soluble P- and L-selectin levels, respectively.
Unlabelled:
In myocardial infarction, the endothelial activation which induces leukocytes migration into the myocardial tissues, may play an important role in ischemic injury. Selectins, shedding from the surface of activated cells into bloodstream, maybe suggested as markers of endothelial activation and leukocytes stimulation. The aim of the study was evaluation. To evaluate serum soluble E- and P-selectin levels as endothelial activation marker and serum soluble L-selectin level as leukocytes stimulation marker in myocardial infarction.
Material And Methods:
We examined 27 patients with acute myocardial infarction (AMI) The control group (K) consisted of 23 healthy subjects without symptoms of coronary artery disease. The concentration of soluble selectins (sE-, sP-, sL-selectin) were analyzed in venous blood serum. Results of routine laboratory tests: lipid levels, leukocyte count, prothrombin time were also included into statistical analysis.
Results:
A significant decrease in serum sL-selectin level was observed in patients with acute myocardial infarction compared to the control group. However, no difference was found in sE- and sP-selectin levels between the patient group and the control group. The sE-selectin level correlated positively with triglicerides level and inversely with HDL cholesterol level. There were a positive correlation between sP-selectin level and leukocyte count as well as inverse correlation between sP-selectin level and prothrombin time. The sL-selectin level correlated positively with leukocyte count. There were also a positive correlation between sP-selectin level and sE-selectin as well as sL-selectin levels.
Conclusions:
The sE-selectin level increases with the severity of atherogenic changes in serum lipid profil, and sP-selectin level increases due to inflammatory and prothrombotic processes. The sL-selectin level is influenced by inflamamatory processes in the vascular wall. The sE- and sP-selectin levels, unchanged compared to the control group, do not reflect adequately the degree of endothelial activation. An decreased sL-selectin level may indicate functional depletion of leukocytes in patients with myocardial infarction and make it difficult to assess the degree of leukocytes stimulation.
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