Related Experiment Video
Updated: May 10, 2026

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice
Published on: January 12, 2024
Advanced glycation end products and diabetic retinopathy
M Chen1, T M Curtis, A W Stitt
1Centre for Vision & Vascular Science, Queen’s University Belfast, Northern Ireland, UK.
Abstract:
Diabetic retinopathy (DR) has a complex pathogenesis which is impacted by a raft of systemic abnormalities and tissue-specific alterations occurring in response to the diabetes milieu. Many pathogenic processes play key roles in retinal damage in diabetic patients. One such pathway is the formation and accumulation of advanced glycation endproducts (AGEs) and advanced lipoxidation end products (ALEs) which are relevant modifications with roles in the initiation and progression of pathology. In this review, AGE/ALE formation in the diabetic retina is discussed alongside their impact on retinal cell function. In addition, various inhibitors of the AGE-RAGE system and their therapeutic utility for DR will also be evaluated.
Related Concept Videos
Diabetic Retinopathy
Diabetic Nephropathy
Diabetic Neuropathy
Complications of Diabetes Mellitus
Hyperglycemia
Diabetes Mellitus: Type 2 and Gestational
