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Updated: May 10, 2026
11:24
Direct Protein Delivery to Mammalian Cells Using Cell-permeable Cys2-His2 Zinc-finger Domains
Published on: March 25, 2015
DNAzyme delivery approaches in biological settings
Cecilia W S Chan1, Levon M Khachigian
1Centre for Vascular Research, University of New South Wales, Sydney, NSW 2052, Australia.
Current Medicinal Chemistry
|June 11, 2013
Summary
DNAzymes, or DNA-based catalysts, show promise for treating genetic disorders. Overcoming cellular delivery challenges is key to their development as novel therapeutic drugs.
Area of Science:
- Biotechnology
- Molecular Biology
- Drug Discovery
Background:
- DNAzymes are catalytic DNA molecules with therapeutic potential for various diseases.
- Current DNAzyme applications are limited by challenges in efficient cellular delivery, especially for systemic treatments.
Purpose of the Study:
- To review existing DNAzyme delivery methods.
- To explore future strategies for enhancing DNAzyme delivery and therapeutic utility.
Main Methods:
- Review of literature on DNAzyme delivery systems.
- Analysis of different carrier agents like polymers and liposomes.
- Discussion of naked DNAzyme delivery approaches.
Main Results:
- Various delivery methods for DNAzymes have been explored, including naked delivery and carrier-assisted approaches.
- Efficient cellular uptake remains a significant hurdle for widespread DNAzyme application.
Conclusions:
- Improved DNAzyme delivery systems are crucial for realizing their potential as novel therapeutic agents.
- Future research should focus on innovative methodologies to enhance DNAzyme delivery and efficacy.
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