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MicroRNAs in peripheral artery disease

Toshio Imanishi1, Takashi Akasaka

  • 1Department of Cardiovascular Medicine, Wakayama Medical University, Japan. t-imani@wakayama-med.ac.jp

Current Topics in Medicinal Chemistry
|June 11, 2013
PubMed

Insights

Peripheral arterial disease (PAD) involves atherosclerosis and abnormal cell growth. This review summarizes how microRNAs (miRNAs) contribute to PAD development and progression.

Area of Science:

  • Vascular Biology
  • Molecular Medicine
  • Genetics

Background:

  • Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerosis.
  • PAD pathology involves abnormal vascular smooth muscle cell proliferation and neointimal hyperplasia.
  • MicroRNAs (miRNAs) are key regulators of gene expression with roles in cardiovascular diseases.

Purpose of the Study:

  • To review the specific roles of microRNAs (miRNAs) in the pathogenesis of peripheral arterial disease (PAD).
  • To highlight the molecular mechanisms by which miRNAs influence PAD development.

Main Methods:

  • Literature review of studies investigating miRNA involvement in PAD.
  • Analysis of research on miRNA regulation of vascular smooth muscle cell proliferation and neointimal lesion formation.

Main Results:

  • Specific miRNAs have been identified as critical players in the pathological processes underlying PAD.
  • miRNAs modulate key pathways involved in vascular remodeling and inflammation in PAD.

Conclusions:

  • MicroRNAs represent significant therapeutic targets for managing peripheral arterial disease (PAD).
  • Further research into miRNA function can lead to novel strategies for PAD treatment.

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