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MicroRNAs in peripheral artery disease
Toshio Imanishi1, Takashi Akasaka
1Department of Cardiovascular Medicine, Wakayama Medical University, Japan. t-imani@wakayama-med.ac.jp
Current Topics in Medicinal Chemistry
|June 11, 2013
Summary
Peripheral arterial disease (PAD) involves atherosclerosis and abnormal cell growth. This review summarizes how microRNAs (miRNAs) contribute to PAD development and progression.
Area of Science:
- Vascular Biology
- Molecular Medicine
- Genetics
Background:
- Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerosis.
- PAD pathology involves abnormal vascular smooth muscle cell proliferation and neointimal hyperplasia.
- MicroRNAs (miRNAs) are key regulators of gene expression with roles in cardiovascular diseases.
Purpose of the Study:
- To review the specific roles of microRNAs (miRNAs) in the pathogenesis of peripheral arterial disease (PAD).
- To highlight the molecular mechanisms by which miRNAs influence PAD development.
Main Methods:
- Literature review of studies investigating miRNA involvement in PAD.
- Analysis of research on miRNA regulation of vascular smooth muscle cell proliferation and neointimal lesion formation.
Main Results:
- Specific miRNAs have been identified as critical players in the pathological processes underlying PAD.
- miRNAs modulate key pathways involved in vascular remodeling and inflammation in PAD.
Conclusions:
- MicroRNAs represent significant therapeutic targets for managing peripheral arterial disease (PAD).
- Further research into miRNA function can lead to novel strategies for PAD treatment.
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