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Updated: May 10, 2026

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

Published on: May 31, 2011

Defining the RGG/RG motif.

Palaniraja Thandapani¹, Timothy R O'Connor, Timothy L Bailey

¹Terry Fox Molecular Oncology Group and Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada.

|June 11, 2013

Summary

The RGG/RG motif, found in over 1,000 human proteins, plays crucial roles in gene regulation and cellular processes. Its involvement in disease highlights the importance of understanding these glycine-arginine-rich domains.

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Area of Science:

Molecular Biology
Genetics
Biochemistry

Background:

Glycine-arginine-rich (GAR) domains and RGG boxes are known functional motifs.
The RGG/RG motif is present in over 1,000 human proteins.
These motifs are implicated in various physiological processes.

Purpose of the Study:

To review the evolving functions of the RGG box and its variations, collectively termed the RGG/RG motif.
To discuss the role of the RGG/RG motif in mediating molecular interactions.
To highlight the motif's relevance in human diseases.

Main Methods:

Literature review of studies on RGG/RG motifs.
Analysis of the motif's involvement in physiological processes like transcription, splicing, DNA damage signaling, translation, and apoptosis.
Examination of RGG/RG motif's role in nucleic acid and protein interactions, including regulation by arginine methylation and partner-binding proteins.

Main Results:

The RGG/RG motif influences numerous cellular functions, including transcription, pre-mRNA splicing, DNA damage signaling, mRNA translation, and apoptosis regulation.
This motif mediates critical nucleic acid and protein interactions.
Arginine methylation and partner-binding proteins modulate RGG/RG motif functions.

Conclusions:

The RGG/RG motif is a functionally diverse and significant element in human proteins.
Its association with diseases such as neurological disorders, neuromuscular diseases, and cancer underscores its physiological importance.
Further research into the RGG/RG motif's emerging functionalities is warranted.