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Related Concept Videos

The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...

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Related Experiment Video

Updated: May 10, 2026

Acrylic Resin Molding Based Head Fixation Technique in Rodents
07:51

Acrylic Resin Molding Based Head Fixation Technique in Rodents

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Fixing a hole where the Ras gets in.

Jeffrey S Iwig1, John Kuriyan

  • 1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Cell
|June 11, 2013
PubMed
Summary

Researchers identified a novel strategy to inhibit Ras, a protein implicated in cancer. Blocking a specific pocket in PDEδ disrupts Ras signaling, offering a promising new avenue for developing effective Ras inhibitors for cancer therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Discovery

Background:

  • Ras proteins are key regulators of cellular signaling pathways.
  • Dysregulation of Ras signaling is a common driver in many human cancers.
  • Developing clinically efficacious Ras inhibitors has been a long-standing challenge in cancer drug discovery.

Purpose of the Study:

  • To identify novel therapeutic targets for Ras-driven cancers.
  • To explore the potential of targeting the interaction between Ras and PDEδ.
  • To investigate a new strategy for developing Ras inhibitors.

Main Methods:

  • The study focused on the interaction between Ras and Phosphodiesterase delta (PDEδ).
  • Researchers investigated blocking a specific pocket within PDEδ that binds to the lipid tail of Ras.

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  • Downstream signaling pathways regulated by Ras were analyzed.

    • Main Results:

    • Blocking the PDEδ pocket effectively disrupted the interaction with Ras.
    • This disruption led to the inhibition of downstream Ras signaling.
    • The findings suggest a new mechanism for targeting Ras.

    Conclusions:

    • Targeting the PDEδ-Ras interaction presents a promising strategy for cancer treatment.
    • This approach offers a potential route to develop novel Ras inhibitors.
    • Further research may lead to new therapies for cancers driven by Ras mutations.