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Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene
K A Lord1, B Hoffman-Liebermann, D A Liebermann
1Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104.
Oncogene
|July 1, 1990
Abstract:
We report here the full length cDNA sequence and the deduced amino-acid sequence of MyD88, a novel myeloid differentiation primary response gene activated in M1D+ myeloid precursors, following induction of terminal differentiation and growth arrest by IL6. Detectable levels of MyD88 RNA were observed in myeloid precursor enriched murine bone-marrow, but not in several other non-myeloid murine tissues.