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Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
06:04

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

Published on: August 8, 2025

An update on transcatheter aortic valve replacement

Mario Gössl, David R Holmes

    Current Problems in Cardiology
    |June 11, 2013
    PubMed

    Insights

    Transcatheter aortic valve replacement (TAVR) offers a life-saving option for severe aortic stenosis patients previously denied treatment. TAVR significantly reduces mortality and is noninferior to traditional surgery in high-risk individuals.

    Area of Science:

    • Cardiovascular Medicine
    • Interventional Cardiology
    • Medical Technology

    Background:

    • Severe symptomatic aortic stenosis historically left inoperable patients with limited options.
    • Transcatheter aortic valve replacement (TAVR) has emerged as a significant advancement.
    • Over 50,000 TAVRs have been performed globally, primarily in Europe.

    Purpose of the Study:

    • To evaluate the efficacy and safety of TAVR in patients with severe symptomatic aortic stenosis.
    • To compare TAVR outcomes against medical therapy and traditional open-heart surgery.

    Main Methods:

    • Analysis of short-term results from the Placement of Aortic Transcatheter Valve (PARTNER) I trial.
    • Review of long-term European/Canadian registry data for TAVR outcomes.

    Main Results:

    • TAVR demonstrated a significant reduction in mortality compared to medical therapy alone in inoperable patients (cohort B).
    • TAVR proved noninferior to open aortic valve replacement in high-risk operable patients (cohort A).

    Conclusions:

    • TAVR is a viable and effective treatment for severe symptomatic aortic stenosis, improving survival rates.
    • Ongoing technical advancements and operator experience are expanding TAVR's applicability to lower-risk populations.

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