[Atherogenic dyslipidemia: a multidisciplinary consensus panel]

    Insights

    Atherogenic dyslipidaemia, marked by high triglycerides or low HDL-cholesterol, is under-recognized. Experts reached consensus on its diagnosis and treatment, though some aspects remain debated.

    Area of Science:

    • Cardiology
    • Metabolic Disorders
    • Public Health

    Context:

    • Dyslipidaemias remain under-diagnosed, under-treated, and poorly controlled globally.
    • Existing data often focuses on hypercholesterolaemia or non-LDL dyslipidaemias in statin-treated patients.
    • Limited information is available on atherogenic dyslipidaemia (high triglycerides and/or low HDL-cholesterol).

    Purpose:

    • To assess expert consensus on the definition, diagnosis, and treatment of atherogenic dyslipidaemia using the Delphi method.
    • To identify areas of agreement and controversy among specialists from various scientific societies.
    • To improve the effective management of this specific lipid anomaly.

    Summary:

    • Experts achieved significant agreement on epidemiological aspects, cardiovascular risk association, clinical identification, and specific treatments for atherogenic dyslipidaemia.
    • Areas of ongoing controversy include the role of isolated hypertriglyceridaemia as a risk factor and therapeutic target.
    • Debate persists regarding HDL-cholesterol's role in cholesterol efflux, individualized therapeutic goals, and the frequent need for combination therapy.

    Impact:

    • Highlights consensus on key aspects of atherogenic dyslipidaemia management.
    • Identifies critical areas requiring further research and clinical discussion.
    • Aims to enhance the control of dyslipidaemia and reduce associated cardiovascular risks.

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