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Related Concept Videos

Transcription Factors02:16

Transcription Factors

82.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Transcription Elongation Factors02:35

Transcription Elongation Factors

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Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
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Transcription Elongation Factors02:35

Transcription Elongation Factors

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No description available
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Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

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No description available
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General Transcription Factors01:30

General Transcription Factors

6.8K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Related Experiment Video

Updated: Jan 26, 2026

Genome-wide Profiling of Transcription Factor-DNA Binding Interactions in Candida albicans: A Comprehensive CUT&RUN Method and Data Analysis Workflow
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Genome-wide Profiling of Transcription Factor-DNA Binding Interactions in Candida albicans: A Comprehensive CUT&RUN Method and Data Analysis Workflow

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Octamer-binding transcription factors: genomics and functions.

Feng-Qi Zhao1

  • 1Department of Animal Science, University of Vermont, Burlington, VT 05405, USA. fzhao@uvm.edu

Frontiers in Bioscience (Landmark Edition)
|June 11, 2013
PubMed
Summary

Octamer-binding proteins (Oct) are crucial transcription factors involved in development and metabolism. Their abnormal function is linked to diseases like cancer and diabetes.

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • Octamer-binding proteins (Oct) are transcription factors binding to the octamer motif (ATGCAAAT).
  • They belong to the POU domain factor family, featuring POUS and POUH subdomains.
  • Eleven Oct proteins (Oct1-11) exist, with eight genes cloned (Oct1, Oct2, Oct3/4, Oct6, Oct7, Oct8, Oct9, Oct11).

Purpose of the Study:

  • To review the genomic structure of Oct proteins.
  • To detail the major functions of individual Oct proteins in physiological and pathological processes.
  • To highlight the role of Oct proteins in various biological events and diseases.

Main Methods:

  • Literature review of genomic structure and functions of Oct proteins.
  • Analysis of expression patterns of different Oct proteins.

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Identifying Transcription Factor Olig2 Genomic Binding Sites in Acutely Purified PDGFR&#945;+ Cells by Low-cell Chromatin Immunoprecipitation Sequencing Analysis
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  • Correlation of Oct protein function with physiological and pathological processes.

    • Main Results:

    • Oct1 and Oct2 show wide adult tissue expression; others have restricted patterns.
    • Oct proteins are vital for embryogenesis, neurogenesis, immunity, and metabolism.
    • Aberrant Oct protein expression or function is linked to deafness, diabetes, and cancer.

    Conclusions:

    • Oct proteins play diverse and critical roles in biological systems.
    • Understanding Oct protein structure and function is essential for comprehending normal physiology and disease pathogenesis.
    • Further research into Oct proteins may offer insights into disease treatment and prevention.