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Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...

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Related Experiment Video

Updated: May 10, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Endothelial progenitor cells and atherosclerosis.

Changwu Ruan¹, Yan Shen, Rui Chen

¹Department of Cardiology, the 8th Renmin Hospital, Shanghai, Shanghai, China. ruancw2012@yeah.net

Frontiers in Bioscience (Landmark Edition)

|June 11, 2013

Summary

Atherosclerosis involves inflammation and endothelial damage. Dysfunction of endothelial progenitor cells (EPCs) contributes to this condition, highlighting their role in vascular repair and potential therapeutic targets.

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Last Updated: May 10, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

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Published on: September 14, 2017

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Area of Science:

Cardiovascular Biology
Cellular Biology
Pathophysiology

Background:

Atherosclerosis is a chronic inflammatory disease of arteries.
Endothelial dysfunction and damage are key pathological features.
Endothelial progenitor cells (EPCs) are crucial for vascular repair and maintenance.

Purpose of the Study:

To elucidate the role of EPCs in the development of atherosclerosis.
To understand how EPC number and function are regulated in vascular repair.
To identify potential therapeutic strategies targeting EPCs for atherosclerosis.

Main Methods:

This study focuses on the pathobiology of atherosclerosis and EPCs.
Review and synthesis of existing literature on EPCs and atherosclerosis.
Analysis of regulatory mechanisms of EPCs in vascular repair.

Main Results:

EPC dysfunction, in both number and function, is implicated in atherosclerosis.
EPCs play a critical role in endothelial repair processes.
Regulation of EPCs is vital for maintaining vascular health.

Conclusions:

Dysfunctional EPCs contribute significantly to atherosclerosis development.
Targeting EPCs offers potential for novel therapeutic interventions.
Further research into EPC biology is warranted for atherosclerosis prevention and treatment.