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Angiogenesis in liver metastasis of colo-rectal carcinoma

Bo Xu¹, Fei Shen, Jie Cao

¹Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical College, Guangzhou 510180, China.

Frontiers in Bioscience (Landmark Edition)

|June 11, 2013

Abstract:

In liver metastasis of color-rectal carcinoma, angiogenesis is supported by vascular endothelial growth factor (VEGF) and E-selectin while it is suppressed by Netrin-4 and LK-68. Sinusoidal endothelial cells and the hepatocyte-derived extracellular matrix support growth of microvessels in liver metastases of color-rectal cancers. Based on these insights, the new treatment for liver metastasis of color-rectal cancers target diverse pathways and molecules of angiogenesis, especially the VEGF pathway. Additional agents target the cyclooxygenase-2 pathway or follow regimens for inhibiting angiogenesis. In this review, we discuss angiogenesis and treatments avaiable for color-rectal liver metastasis.

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