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Updated: May 10, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
Inhibition of herpesvirus and influenza virus replication by blocking polymerase subunit interactions
Giorgio Palù1, Arianna Loregian
1Department of Molecular Medicine, University of Padua, via Gabelli 63, 35121 Padua, Italy.
Abstract:
Protein-protein interactions (PPIs) play a key role in many biological processes, including virus replication in the host cell. Since most of the PPIs are functionally essential, a possible strategy to inhibit virus replication is based on the disruption of viral protein complexes by peptides or small molecules that interfere with subunit interactions. In particular, an attractive target for antiviral drugs is the binding between the subunits of essential viral enzymes. This review describes the development of new antiviral compounds that inhibit herpesvirus and influenza virus replication by blocking interactions between subunit proteins of their polymerase complexes.
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