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FGF23 modifies the relationship between vitamin D and cardiac remodeling
Bonnie Ky1, Justine Shults, Martin G Keane
1Renal Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Circulation. Heart Failure
|June 11, 2013
Summary
Low vitamin D and high FGF23 levels are linked to increased heart size in chronic kidney disease patients. Understanding these hormone interactions is key for managing cardiac remodeling and potential treatments.
Area of Science:
- Nephrology
- Cardiology
- Endocrinology
Background:
- Growing evidence suggests vitamin D, parathyroid hormone, and FGF23 play roles in chronic kidney disease (CKD) cardiac remodeling.
- The interplay between these hormones and cardiac structure in CKD requires further elucidation.
Purpose of the Study:
- To investigate the relationship between vitamin D metabolites and cardiac remodeling in CKD patients.
- To determine the modifying effects of parathyroid hormone and FGF23 on these associations.
Main Methods:
- Quantitative echocardiography was performed on 1431 participants from the Chronic Renal Insufficiency Cohort study.
- Measurements included 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), FGF23, and parathyroid hormone.
- Linear regression models were used to analyze interactions between vitamin D, FGF23, and cardiac remodeling parameters.
Main Results:
- Significant negative interactions were found between 25(OH)D and FGF23 concerning left ventricular (LV) mass and volumes.
- Low 25(OH)D and high FGF23 levels were associated with increased LV mass and cavity dilatation.
- These interactions were also observed for 1,25(OH)2D, but parathyroid hormone did not modify these effects.
Conclusions:
- Significant interactions exist among vitamin D metabolites (25(OH)D, 1,25(OH)2D) and FGF23 in relation to cardiac remodeling in CKD.
- The combined assessment of vitamin D and FGF23 is crucial for understanding their impact on cardiac remodeling.
- These findings highlight potential therapeutic targets for managing cardiac complications in CKD.
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