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Patient preference clinical trials: why and when they will sometimes be preferred
Charles Joseph Kowalski1, Adam Joel Mrdjenovich
1Health and Behavioral Sciences IRB, University of Michigan, Ann Arbor, MI 48104-2210, USA. chuckk@umich.edu
Perspectives in Biology and Medicine
|June 11, 2013
Summary
Preference clinical trials (PCTs) are valuable when comparing health interventions where blinding is difficult and patient choice is a factor. These trials allow researchers to understand treatment effectiveness in patients who actively choose their intervention.
Area of Science:
- Clinical Trials Methodology
- Health Services Research
Background:
- Preference clinical trials (PCTs) offer an alternative to randomized controlled trials (RCTs).
- PCTs accommodate patient preferences when interventions are difficult to blind.
Purpose of the Study:
- To advocate for the consideration of PCTs in specific clinical trial scenarios.
- To highlight the utility of PCTs when comparing interventions with inherent patient preference.
Main Methods:
- Discusses the design considerations for PCTs based on the clinical question.
- Positions PCTs on the pragmatic end of the explanatory/pragmatic clinical trial spectrum.
Main Results:
- PCTs are suitable for situations where blinding is not feasible and patient choice is prevalent.
- The design of PCTs should be guided by the specific research question.
Conclusions:
- PCTs provide valuable insights into treatment effectiveness for patients who select their intervention.
- These trials can positively impact clinical decision-making in real-world settings.
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