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Styrene altered clock gene expression in serum-shocked cultured human fibroblasts

Nicola Manzella1, Massimo Bracci, Sara Staffolani

  • 1Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy.

Bioscience, Biotechnology, and Biochemistry
|June 11, 2013
PubMed

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...