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Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound (fTCD)

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Published on: September 27, 2010

Gender differences in regional cerebral blood flow.

R E Gur¹, R C Gur

¹University of Pennsylvania, Brain Behavior Laboratory, Philadelphia 19104.

Schizophrenia Bulletin

|January 1, 1990

Summary

Women exhibit higher regional cerebral blood flow (rCBF) than men, a difference influenced by age. This pattern persists in schizophrenia, warranting further investigation into its clinical correlates.

Area of Science:

Neuroscience
Medical Imaging

Background:

Neurobehavioral studies reveal gender differences in brain function.
Regional cerebral blood flow (rCBF) measurements can elucidate the neural basis of these differences.
Existing research on sex differences in rCBF is limited, particularly in clinical populations.

Purpose of the Study:

To examine gender differences in regional cerebral blood flow (rCBF).
To investigate the relationship between age and rCBF in men and women.
To explore sex differences in rCBF within the context of schizophrenia.

Main Methods:

Utilized the 133xenon inhalation method for measuring rCBF.
Analyzed data from studies involving normal subjects and patients with schizophrenia.
Compared rCBF values between genders and across different age groups.

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Main Results:

In normal subjects, women generally demonstrate higher rCBF than men, with this difference diminishing with age.
By the sixth decade, rCBF rates tend to become similar between sexes.
The pattern of higher rCBF in females was observed in schizophrenia studies, though less frequently examined.

Conclusions:

Gender influences regional cerebral blood flow, with women typically exhibiting higher rates.
Age is a significant factor modulating gender differences in rCBF.
Further research is needed to understand the clinical and functional correlates of observed sex differences in rCBF, especially in schizophrenia.