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[Sicca syndrome in amyloidosis].

G P Ramelli1, C Marone, J O Gebbers

  • 1Medizinische Klinik, Kantonsspital Luzern.

Schweizerische Medizinische Wochenschrift
|July 10, 1990
PubMed
Summary

Sicca syndrome, characterized by dry eyes and mouth, can be caused by amyloidosis, a protein buildup disorder. This research highlights amyloidosis as a potential, often overlooked, cause of sicca syndrome.

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Area of Science:

  • Rheumatology
  • Nephrology
  • Pathology

Background:

  • Rheumatoid arthritis and sicca syndrome can be linked to amyloidosis.
  • Amyloidosis involves the abnormal deposition of proteins, leading to organ damage.

Observation:

  • Two patients with rheumatoid arthritis and sicca syndrome had secondary amyloidosis (A-amyloid) affecting kidneys and gut.
  • Autopsies revealed generalized amyloidosis with deposits in salivary and lacrimal glands.
  • Two other patients developed sicca syndrome from primary systemic L-amyloidosis, experiencing renal insufficiency and cardiac issues.

Findings:

  • Sicca syndrome associated with amyloidosis is potentially more common than previously thought.
  • Systemic L-amyloidosis can lead to severe complications, including cardiac failure.

Implications:

  • Amyloidosis should be considered in the differential diagnosis of sicca syndrome.
  • Early detection of amyloidosis may improve patient outcomes in sicca syndrome cases.

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