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Published on: March 12, 2016
Topiramate-induced angle-closure glaucoma: cross-sensitivity with other sulphonamide derivatives causing anterior
Saurabh Kamal1, Usha Yadava, Sushil Kumar
1Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, 110002, India, drskamal@gmail.com.
Abstract:
Topiramate is a recognized cause of drug-induced acute angle-closure glaucoma. We describe a case presenting with bilateral acute angle-closure glaucoma caused by topiramate intake. Patient subsequently developed severe anterior uveitis caused by sulphonamide derivatives (acetazolamide and co-trimoxazole) due to cross-sensitivity, on two separate occasions. The present case also highlights the role of anterior segment optical tomography in diagnosis and follow-up. In a patient with known drug allergy to topiramate, other sulphonamide derivatives should be avoided to limit the ocular morbidity.
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