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Stimulation of phospholipase C-gamma 1 membrane association by epidermal growth factor
G Todderud1, M I Wahl, S G Rhee
1Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.
Science (New York, N.Y.)
|July 20, 1990
Abstract:
Epidermal growth factor (EGF) treatment of A-431 epidermoid carcinoma cells elicited a redistribution of phospholipase C-gamma 1 (PLC-gamma 1) from a predominantly cytosolic localization to membrane fractions. The temporal coincidence of this redistribution with EGF stimulation of inositol phosphate formation and EGF increased phosphorylation of PLC-gamma 1 suggests that the membrane association of PLC-gamma 1 is a significant event in second messenger transduction.