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Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
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Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

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FGFR fusions in the driver's seat

Amit J Sabnis1, Trever G Bivona

  • 1Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA.

Cancer Discovery
|June 11, 2013
PubMed

Insights

Researchers found new fibroblast growth factor receptor (FGFR) fusion proteins in various cancers. Inhibiting FGFR slowed tumor growth, indicating these fusions drive cancer and can be targeted for treatment.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Fibroblast growth factor receptor (FGFR) alterations are implicated in cancer development.
  • Identifying specific oncogenic drivers is crucial for targeted cancer therapies.

Purpose of the Study:

  • To identify novel oncogenic driver proteins through clinical deep sequencing.
  • To investigate the therapeutic potential of targeting identified FGFR fusions.

Main Methods:

  • Utilized a clinical deep sequencing protocol to analyze tumor samples.
  • Tested pharmacologic inhibition of FGFR in preclinical tumor models.

Main Results:

  • Identified multiple FGFR fusion proteins across diverse cancer types.
  • Demonstrated that FGFR inhibition suppressed tumor growth in FGFR fusion-positive models.

Conclusions:

  • FGFR fusions act as oncogenic drivers in various human cancers.
  • Streamlined clinical sequencing is effective for discovering actionable oncoproteins.
  • Targeting FGFR fusions represents a promising therapeutic strategy.

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